https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:279 8,000 infections and > 700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.]]> Wed 11 Apr 2018 11:07:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8419 Sat 24 Mar 2018 08:40:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7329 Sat 24 Mar 2018 08:35:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7261 Sat 24 Mar 2018 08:33:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6773 Sat 24 Mar 2018 07:48:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6774 Sat 24 Mar 2018 07:48:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4971 Sat 24 Mar 2018 07:46:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4965 50% cells positive) was displayed mostly in HGD and AdenoCa (46.7% and 42.3%, respectively). Ki-67 index increased with the severity of dysplasia and labeling extended from the lower third of the crypts to the superficial epithelium. The frequency of AMACR-positivity was 12% in BE, 47.1% in IND, 44.4% in LGD, 93.3% in HGD, and 96.2% in AdenoCa. The intensity and extent of AMACR staining also increased with the severity of dysplasia. Aberrant p16 and high-cyclin D1 expression may reflect early genetic events during the progression of Barrett-associated carcinogenesis. Cytoplasmic staining of p16 is specific. It may represent a different pathway of p16 dysfunction. The pattern and extent of Ki-67 staining and AMACR overexpression are useful additional parameters for identifying dysplasia in BE.]]> Sat 24 Mar 2018 07:46:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:314 Sat 24 Mar 2018 07:42:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:330 Sat 24 Mar 2018 07:42:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:360 Sat 24 Mar 2018 07:42:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4801 Sat 24 Mar 2018 07:20:40 AEDT ]]>